To summarize the nursing experience of a patient with huge space occupying of cardiac non-Hodgkin lymphoma. The key points of nursing include:monitoring and volume management of circulatory system,predictive nursing of percutaneous ventricular septal biopsy,nursing of individual chemotherapy complications,rehabilitation guidance during acute heart failure in bed,risk management of cross-hospital transport,and individual psychological nursing. After careful multidisciplinary treatment and nursing care,the patient was getting better;the heart tumor was smaller than before;the cardiac function increased from level Ⅳ to Ⅱ;no chest tightness,shortness of breath and discomfort were reported after walking on the ground for 30 min.